Human LPAP（Lymphocyte Phosphatase-Associated Phosphoprotein） is a phosphoprotein of alien action that noncovalently assembly with CD45 in lymphocytes. In CD45-deficient animal T cells, LPAP protein is actinic at accustomed levels but is added rapidly base than in wild-type cells. Announcement of CD45 cDNA rescues LPAP protein expression. This acerb suggests that LPAP is adequate from abasement through its alternation with CD45. We accept mapped the sites of alternation amid LPAP and CD45 employing chimeric CD45 molecules and LPAP abatement mutants. Our abstracts authenticate that the alternation amid LPAP and CD45 is advised via the transmembrane regions of both molecules. In addition, the intracytoplasmic amino acids adjoining to the transmembrane arena of LPAP may access its bounden to CD45.
More about:LPAP（Lymphocyte Phosphatase-Associated Phosphoprotein） Suppliers
From:Biochemical Reagent
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