First reported in 1985 Glu Sladeczek activation of G protein-coupled receptors. 1991 Houamed etc. from rat cerebellum cDNA library cloned out of the mGluR1. 1992 年 researchers mGluR1 probe made from mouse brain cDNA library isolated mGluR5 (Anti-GRM5 (Glutamate Receptor Metabotropic 5)）. mGluR5 length of the cDNA is 3 918bp, encoding a 171 amino acid residues, a molecular weight of 128 289. mGluR5 consists of three parts: The first part is the function of the extracellular region, including the 560 amino acid residues, which has the potential glycosylation of tion sites, a signal peptide of the N-terminal; second portion by a hydrophobic region 7 formed in the cell membrane seven transmembrane region, this area has 261 amino acid residues; third part is the function of the cell area, the 350 amino acid residues, the C-terminal phosphorylation sites are many and threonine, serine residue, suggests that this region may be adjusted several kinase receptor target [3] in the human and rat mGluR5 7th a transmembrane region of the cytoplasm and after the insertion end 50, respectively, and 32 amino acid residues, does not cause GluR5 pharmacological properties of the changes, which will initially be cloned mGluR5 named mGluR5a, the named after insertion mG1uR5 mGluR5b, in the adult rat brain mG1uR5b mRNA expression than mGluR5a.
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