Heme oxygenase (Anti-HO-2 (Heme oxygenase 2)) is in the process of heme catabolism rate-limiting enzyme in the human body of CO is dominated by heme oxygenase (HO) metabolites produced. HO There are three types: oxidative stress inducible (HO-1), constitutive (HO-2) and remained clear HO-3. Studies show that, HO-1 in the body not only play a role in the physiological state, but mainly in the body, or other non-normal stress play a role. HO-2 is mainly distributed in the central nervous system and testicular, HO-2 CO produced in the nerve plays an important role in signal transduction, and CO neurotransmitters play closely related. Many scholars on ways to produce CO and HO carried out a detailed study that through this - pathways of CO speed and quantity of 0.4ml / h (16.4/μmol/h). It is known HO distributed in almost all the organs and tissues, and involves the growth process, which prompts the production of CO can be very wide area. Currently a large number of studies have confirmed CO is important in vivo cell messenger, heart, brain and vascular system plays an important biological effect, involved in the regulation of many physiological and pathological processes in vivo. Meanwhile, CO as a novel neurotransmitter is also cause for concern, and its role in the nervous system and its clinical significance in research, neuroscience has become a new hotspot.
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