Overview of 1,3-Dihydroxynaphthalene

Name : 1,3-Dihydroxynaphthalene
CAS : 132-86-5
Molecular Formula : C10H8O2
Formula Weight : 160.17
Description :
Chemical Properties ：orange-pink to brown crystalline powder
mp： 123-125 °C(lit.)
form  ：crystalline
color：  white to tan
Sensitive ： Light Sensitive
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Description of L-arginine

L-arginine is an amino acid that has numerous functions in the body. It helps the body get rid of ammonia (a waste product), is used to make compounds in the body such creatine, L-glutamate, and L-proline, and can be converted to glucose and glycogen if needed. -arginine is used to make the nitric oxide, a compound in the body that relaxes blood vessels. Preliminary studies have found that L-arginine may help with conditions that improve when blood vessels are relaxed (called vasodilation), such as atherosclerosis, erectile dysfunction, and intermittent claudication.
Name :  L(+)-Arginine
CAS : 74-79-3
Molecular Formula : C6H14N4O2
Formula Weight : 174.2
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Overview of Carnosic acid

Name : Carnosic acid
CAS : 3650-09-7
Molecular Formula : C20H28O4
Formula Weight : 332.43g/mol
Description :
It is light yellow to greenish yellow powder or Dark yellow to yellow brownish sticky liquid.Carnosic acid is used as strong antioxidant in oily products, such as edible oil and grease, feeds, deep-sea fish oil, DHA, EPA, AA, infant and senior nutrition powder, baked or fried foods, aquatic product, meat, flour, seasoning, candy, health care products, bio-pesticide, pharmaceuticals, cosmetics, biopesticide, tobacco, etc.
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Overview of Cynarin

Name : Cynarin
CAS : 1182-34-9
Molecular Formula : C25H24O12
Formula Weight : 516.45g/mol
Description :
Cynarin (Artichoke Concentrate) reduces cholesterol production by the liver and expels sluggish cholesterol out of the liver and gallbladder, thus stimulating liver bile production and flow, which in turn is used to breakdown fat.  It lowers elevated blood lipids (fats) such as serum cholesterol and triglycerides.  It raises good HDL cholesterol level and protects the liver and enhances liver function.
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about (R)-(+)-2-phenylpropylamine

name:(R)-(+)-2-phenylpropylamine
CAS:     28163-64-6
Molecular Formula:     C9H13N
Formula Weight:135.21
Description:
Boiling point:197 ºC
Flash Point:178 ºF
Density:0.940 g/mL at 20 °C(lit.)
Related classes:Amines;Chiral Compounds;chiral;Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;Chiral Compound

Eldecalcitol is acclimated to amusement osteoporosis

Eldecalcitol is a biologic acclimated for the assay of osteoporosis. It is an analog of vitamin D. Osteoporosis is a accepted cartilage ache a allotment of the earlier generation, with an estimated prevalence of over 200 actor people.This activity about after-effects in cartilage fractures due to abnormally low cartilage accumulation density, and is a arch could could could could cause of disability, abnormally a allotment of developed countries with best boilerplate activity spans. Osteoporosis is added accepted in women than with men.
Eldecalcitol added cartilage mineral physique and bargain cartilage about-face markers greater than alfacalcidol and placebo. Interestingly, in a 3-year analytic trial, cartilage absorption cast remained suppressed during the eldecalcitol treatment, admitting cartilage accumulation markers gradually recovered afterwards antecedent suppression. The incidences of vertebral fractures and wrist fractures in eldecalcitol-treated accumulation were decidedly lower than those in alfacalcidol-treated accumulation by 26 and 71%, respectively. In the patients whose baseline cartilage about-face was low, eldecalcitol assay did not added abolish cartilage about-face markers during the 3-year assay period.

from:Acridine Raw Material

Introduction of Copper(II) chloride dihydrate

Substance:Copper(II) chloride dihydrate
Molecular formula: H4Cl2CuO2
Molar mass: 170.483
Melting point: 100 °C
Copper(II) chloride is the actinic admixture with the actinic blueprint CuCl2. This is a ablaze amber solid, which boring absorbs damp to anatomy a blue-green dihydrate. The copper(II) chlorides are some of the a lot of accepted copper(II) compounds, afterwards chestnut sulfate.
For analysis use. Not accessible for analytic or therapeutic.
This is classified as a Dangerous Good for carriage and may be accountable to added shipment charges.

from:Rare Metals

Research of Tectorigenin on cardiovascular disease

Tectorigenin is a bulb isoflavonoid originally abandoned from the broiled annual of Pueraria thomsonii Benth. Although its anti-inflammatory and anti-hyperglycosemia furnishings accept been able-bodied documented, the aftereffect of tectorigenin on endothelial dysfunction insulin attrition complex has not yet been reported. Herein, this abstraction aims to investigate the activity of tectorigenin on advancement of insulin attrition in the endothelium. Palmitic acerbic (PA) was called as a analeptic to abet ROS assembly in endothelial beef and auspiciously accustomed insulin attrition apparent by the specific crime of insulin PI3K signaling. Tectorigenin finer inhibited the adeptness of PA to abet the assembly of acknowledging oxygen breed and collapse of mitochondrial film potential. Moreover, tectorigenin presented able inhibition aftereffect on ROS-associated inflammation, as TNF-α and IL-6 assembly in endothelial beef was abundantly bargain with abolishment of IKKβ/NF-κB phosphorylation and JNK activation. Tectorigenin aswell can arrest inflammation-stimulated IRS-1 serine phosphorylation and restore the broken insulin PI3K signaling, arch to a decreased NO production. These after-effects approved its absolute adjustment of insulin activity in the endothelium. Meanwhile, tectorigenin down-regulated endothelin-1 and vascular corpuscle adherence molecule-1 overexpression, and adequate the accident of insulin-mediated vasodilation in rat aorta. These allegation appropriate that tectorigenin could arrest ROS-associated deepening and ameliorated endothelial dysfunction alive in insulin attrition through acclimation IRS-1 function. Tectorigenin adeptness accept abeyant to be activated for the administration of cardiovascular diseases complex in diabetes and insulin resistance.
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about Panaxtriol

name:Panaxtriol
CAS   :32791-84-7
Molecular Formula:C30H52O4
Molecular Weight:476.7315
Density:1.068g/cm3
Boiling Point:561.5°C at 760 mmHg
Flash Point :293.4°C
Steam Vapour:6.04E-15mmHg at 25°C

from:Acridine Raw Material

about Chlorogenic acid

Chlorogenic acid is a accustomed admixture begin in raw blooming coffee beans but if the coffee beans are roasted, the chlorogenic acid is mostly destroyed. So, the abeyant advantageous allowances from bubbler approved coffee (i.e. coffee brewed from broiled coffee bean) would acceptable be decidedly beneath than if demography a blooming coffee chlorogenic acid comestible supplement.
Chlorogenic acid is begin in coffee and espresso, although the bulk appears to be unreliable.
Chlorogenic acid may be one of the compounds in prunes that aids in the laxative effect.It is aswell in coffee, addition able-bodied accepted aliment laxative.
Chlorogenic acid has a anemic psychostimulatory effect, about a third as almighty as Caffeine.
Chlorogenic acid and Caffeic acid were already anticipation to be anti-thaminases (compounds that can abet a thiamin (Vitamin B1) deficiency), however, this has back been apparent to be false.

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Research Toosendanin treatments for botulinum neurotoxin

Botulinum neurotoxins (BoNT) arrest the action of neurotransmitter absolution at presynaptic motor assumption terminals, causing beef paralysis. The adeptness of botulinum adulteration to aftermath its aftereffect is abased on the adeptness of the ablaze alternation to carve the SNARE proteins associated with transmitter release. About-face of the ablaze alternation protease through the abundant chain-formed approach is a cardinal footfall in the beatitude process. Toosendanin (TSN), a triterpenoid acquired extracted from a Chinese acceptable medicine, has been accustomed to be an able cure for beginning botulism. This abstraction was advised to analyze the antibotulismic mechanisms of toosendanin.
The chaotic single-channel recording patch-clamp address was acclimated to almanac the BoNT/A-induced currents in the attendance and absence of TSN.
Approach accumulation was delayed and the sizes of the channels were bargain in the TSN-treated PC12 corpuscle membrane.
The antibotulismic aftereffect of TSN adeptness action via arrest with adulteration translocation.

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Ubenimex is a protease inhibitor

Ubenimex (INN), also known by the brand name bestatin, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, and aminopeptidase N. It is derived from Streptomyces olivoreticuli.
An immunomodulating agent, ubenimex has low toxicity even after long-term oral administration and brings about significant modifications in immunological response. In a cooperative randomized controlled study of ubenimex  immunotherapy for adult acute nonlymphocytic leukemia, prolongation of remission duration and survival was achieved with ubenimex  immunotherapy combined with remission maintenance chemotherapy. The significant prolongation of remission duration and survival was seen in the ubenimex  group, especially in the elderly patients. Randomized controlled studies of ubenimex  immunotherapy were performed in solid tumors including malignant melanoma, carcinoma of the lung, stomach, bladder, head and neck and esophagus, and therapeutic benefits regarding disease free-interval or survival were observed in certain types of the above-mentioned cancers; however, ubenimex  immunotherapy for these cancers should be further investigated in large-scale controlled studies to confirm its activity.

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Lentinan for cancer chemotherapy

Lentinan is an intravenous anti-tumor polysaccharide isolated from the fruit body of shiitake (Lentinula edodes). Lentinan has been approved as an adjuvant for stomach cancer in Japan since 1985. Lentinan is one of the host-mediated anti-cancer drugs which has been shown to affect host defense immune systems.
Lentinan is used widely in Japan and China as an adjuvant to cancer chemotherapy. It is also used for upregulating the immune system;
Medical professionals use lentinan to boost the effects of regular medicines used for treating cancer and HIV infection. They give lentinan intravenously (by IV) or as a shot (by injection).

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Bimatoprost applied to the eyes

Bimatoprost is a prostaglandin analog/prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. It reduces intraocular pressure (IOP) by increasing the outflow of aqueous fluid from the eyes. In December 2008, the indication to lengthen eyelashes was approved by the U.S. Food and Drug Administration (FDA); the cosmetic formulation of bimatoprost is sold as Latisse. In 2008-2011, at least three case series suggested that bimatoprost has the ability to reduce adipose (fat) tissue..
Treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma.
Bimatoprost drops is a prostaglandin analog. It works to lower pressure in the eye by increasing fluid drainage from the eye.

from:Acridine Raw Material

Ubenimex is a protease inhibitor

Ubenimex (INN), also known by the brand name bestatin, is a competitive protease inhibitor. It is an inhibitor of aminopeptidase B, leukotriene A4 hydrolase, and aminopeptidase N. It is derived from Streptomyces olivoreticuli.
An immunomodulating agent, ubenimex has low toxicity even after long-term oral administration and brings about significant modifications in immunological response. In a cooperative randomized controlled study of ubenimex  immunotherapy for adult acute nonlymphocytic leukemia, prolongation of remission duration and survival was achieved with ubenimex  immunotherapy combined with remission maintenance chemotherapy. The significant prolongation of remission duration and survival was seen in the ubenimex  group, especially in the elderly patients. Randomized controlled studies of ubenimex  immunotherapy were performed in solid tumors including malignant melanoma, carcinoma of the lung, stomach, bladder, head and neck and esophagus, and therapeutic benefits regarding disease free-interval or survival were observed in certain types of the above-mentioned cancers; however, ubenimex  immunotherapy for these cancers should be further investigated in large-scale controlled studies to confirm its activity.

from:Acridine Raw Material

Clofarabine for the treatment of cancer

Clofarabine is used to treat acute lymphoblastic leukemia that has come back or that did not improve with at least 2 regimens of chemotherapy. It's used in children and young adults up to 21 years of age. It may also be used for other types of cancer.
Clofarabine is used to treat acute lymphoblastic leukemia (ALL; a type of cancer of the white blood cells) in children and young adults 1 to 21 years old who have already received at least two other treatments. Clofarabine is in a class of medications called purine nucleoside antimetabolites. It works by killing existing cancer cells and limiting the development of new cancer cells.

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What is 4-Bromothiazole?

Name: 4-Bromothiazole
CAS Number: 34259-99-9
Molecular Weight: 164.02
Molecular Formula: C3H2BrNS
assay  :97%
refractive index   n20/D 1.602
density   1.839 g/mL at 25 °C
Available Spectra: NMR, HPLC, LCMS
Physical Form: Colorless to light yellow to light brown liquid
Flash Point: 102°C
Refractive Index: n20/D1.602
Shipping: Normal Temperature

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Introduction and Purpose of Felodipine

Felodipine is an articulate calcium- approach acquaintance (CCB) of the dihydropyridine (DHP) class. Added calcium approach blockers in the DHP chic cover nifedipine (Procardia, Adalat), amlodipine (Norvasc), nisoldipine (Sular), nicardipine (Cardene), and isradipine (Dynacirc). Calcium is all-important for beef beef to contract. Felodipine prevents calcium from getting appear aural the beef beef of the baby arteries and thereby causes the anatomy to relax and the arteries to amplify or expand. Dilation of arteries reduces claret pressure. Felodipine has little or no aftereffect on the anatomy of veins or the heart. Felodipine was accustomed by the FDA in 1991.

Felodipine is acclimated to amusement top claret burden (hypertension). Lowering top claret burden helps anticipate strokes, affection attacks, and branch problems. Felodipine is accepted as a calcium approach blocker. By blocking calcium, this medication relaxes and widens claret argosy so claret can breeze added easily.
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Mechanism of Ulex Europaeus agglutinin

Ulex europaeus agglutinin binds to abounding glycoproteins and glycolipids absolute α-linked fucose residues, such as ABO claret accumulation glycoconjugates. This lectin preferentially binds claret accumulation O beef and has been acclimated to actuate secretor status. It has been accustomed as an accomplished brand for beastly endothelial cells.
Biotinylated Ulex europaeus agglutinin has an adapted bulk of biotins apprenticed to accommodate the optimum staining characteristics for this lectin. This conjugate is supplied about chargeless of unconjugated biotins and is preserved with sodium sodium azide.
This biotinylated lectin is an ideal average for analytical glycoconjugates application the Biotin-Avidin/Streptavidin System. Aboriginal the biotinylated lectin is added, followed by the VECTASTAIN® ABC Reagent, Avidin D conjugate, or streptavidin derivative.
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Anti-CBX5 introduction

CBX5, aswell accepted as Chromobox protein homolog 5, is a authoritative protein acceptance to the Polycomb accumulation proteins ancestors with two chromo domains. CBX5 accumulation with chromosomes during mitosis, accurately with chromatin during metaphase and anaphase. A basic of the centromeric and pericentromeric heterochromatin, CBX5 may collaborate with lamin B receptor (LBR) to accord to the affiliation of the heterochromatin with the close nuclear membrane. CBX5 recognizes and binds histone H3 cape methylated at 'Lys-9', arch to epigenetic repression. This methyl-lysine bounden protein localized at heterochromatin sites is aswell accepted to arbitrate gene silencing and is circuitous in the accumulation of anatomic kinetochore through alternation with MIS12 circuitous proteins.
Description
This antiseptic recombinant abrasion monoclonal antibiotic recognizes CBX5 in animal samples.
Recombinant antibiotic characteristics include:
• Validation in Immunoprecipitation
• Superior lot-to-lot consistency
• Acutely top specificity and sensitivity
• Recombinant abrasion monoclonal antibody
• Specific for CBX5

CBX-5, or Chromobox homolog 5, is encoded by the cbx5 gene amid on chromosome 12. CBX-5 is aswell accepted as Heterochromatin Protein 1 Homolog alpha (HP1 alpha). This protein is ubiquitously bidding and localized in the basis (1). CBX 5 is a basic of the centromeric and pericentromeric heterochromatin and binds the heterochromatin to the lamin B receptor present on the close nuclear membrane. CBX-5 aswell aids in epigenetic repression by bounden to the methylated Lys-9 (H3K9me) residues on histone H3 cape (2).
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Tripotassium Glycyrrhizinate Introduction

Chemical Name:
18b-Glycyrrhizic acerbic tripotassiumsalt
CAS No.
68797-35-3
Molecular Formula:
C42H60K3O16
Molecular Weight:
938.1128
Solubility: agnate white or chicken accomplished powder .This artefact is extracted from accustomed licorice and bogus through appropriate technology. With its capital basal as glycyrrhizic acid. It is calmly solvable in water.
Applications: Method of application: It is appropriate to aboriginal break this artefact with baptize at an ambient temperature
Dosage of application: It is recommended that the appliance bulk shall be 5‰

Stability and Storage: It is all-important to abundance in black and closed in dry place.

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calmodulin-dependent protein kinase II (CaMKII) favors myocardial dysfunction and corpuscle film electrical alternation

Understanding relationships amid affection abortion and arrhythmias, important causes of adversity and abrupt death, charcoal an unmet ambition for biomedical advisers and physicians. Affirmation accumulated over the accomplished decade supports a appearance that activation of the multifunctional Ca2+ and calmodulin-dependent protein kinase II (CaMKII) favors myocardial dysfunction and corpuscle film electrical instability. CaMKII activation follows increases in intracellular Ca2+ or oxidation, upstream signals with the accommodation to alteration CaMKII into a Ca2+ and calmodulin-independent constitutively alive enzyme. Constitutively alive CaMKII appears assertive to participate in ache pathways by catalyzing the phosphorylation of classes of protein targets important for excitation–contraction coupling and corpuscle survival, including ion channels and Ca2+ homeostatic proteins, and archetype factors that drive hypertrophic and anarchic gene expression. This affluent assortment of afterwards targets helps to explain the abeyant for CaMKII to accompanying affect automated and electrical backdrop of affection beef cells. Proof-of-concept studies from a growing amount of board appearance that CaMKII inhibition is amiable for convalescent myocardial achievement and for abbreviation arrhythmias. We analysis the atomic analysis of CaMKII and altercate CaMKII accomplishments at key cellular targets and after-effects of beastly models of myocardial hypertrophy, dysfunction, and arrhythmias that advance CaMKII inhibition may account myocardial action while abbreviation arrhythmias

CD166 's Introduction

Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a 105 kD cell-surface adherence atom acceptance to the Ig superfamily of receptors. ALCAM is a blazon I transmembrane glycoprotein, possessing 5 extracellular Ig domains, a transmembrane domain, and a abbreviate cytoplasmic tail. ALCAM is complex in homotypic adhesion, as able-bodied as heterotypic adherence with its accustomed ligand, CD6. A acrid isoform of ALCAM has been apparent to arrest homophilic adhering interactions. ALCAM is bidding on a array of corpuscle types, including activated T and B cells, monocyte-derived blooming cells, and thymic epithelial cells. ALCAM announcement has aswell been acclimated as a brand for the abreast of pluripotent axis cells.

Stability of the Human Dystrophin Transcript in Muscle

The human dystrophin gene has 79 exons spanning >2300 kb making it the largest known gene. In previous studies we showed that ∼16 h are required to transcribe the gene in myogenic cultures [Tennyson,C.N., Klamut,H.J. and Worton,R.G. (1995) Nature Genet. 9, 184–190]. To estimate the half-life of the dystrophin mRNA, the decay of the transcript was monitored by quantitative RT-PCR in cultured human fetal myotubes following exposure to actinomycin D. Results from this analysis indicated that the half-life of the dystrophin mRNA is 15.6 ± 2.8 h in these cultures. Transcript accumulation profiles were predicted using a mathematical model which incorporated the measured half-life. The modeled accumulation profiles were consistent with observed profiles supporting the half-life measured using actinomycin D. The kinetic model was then used to predict the relative amount of nascent and mature dystrophin transcript at steady state. Measurements by quantitative RT-PCR indicated that in adult skeletal muscle tissue the concentration of mature dystrophin mRNA is 5–10 molecules per nucleus, demonstrating, as expected, that it is a low abundance transcript. Furthermore the ratio of nascent to mature dystrophin transcript indicated that dystrophin synthesis may not be at steady state in the adult skeletal muscle we tested. Alternatively, the kinetics of transcript production in skeletal muscle tissue may be different from those observed in cultured fetal myogenic cells.

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Early Prostate Cancer Antigen-2: A Controversial Prostate Cancer Biomarker?

It is well known that prostate-specific antigen (PSA)1 has both advantages and disadvantages as a marker of prostate cancer. Advantages include its ability to effectively detect early-stage prostate cancer and to monitor disease progression. A disadvantage of PSA is that prostate cancer cells and normal prostate cells both produce PSA; thus, it is frequently increased in nonmalignant conditions such as prostatitis and benign prostatic hyperplasia. The low diagnostic specificity of PSA leads to many false positives and a large number of biopsies in patients who are suspected to have prostate cancer. These well-recognized limitations of PSA suggest that new, and improved, prostate cancer biomarkers could play a useful role in reducing the number of unnecessary biopsies.
Over the last 10 years, many candidate prostate cancer biomarkers have been proposed (1). None of them has as yet reached the clinic, owing to their inferiority when compared with PSA. Getzenberg et al. published two provocative reports, one in the journal Urology (2) and a more recent one in the journal The Prostate (3), claiming that a newly discovered prostate cancer biomarker, early prostate cancer antigen-2 (EPCA-2), may be more effective than PSA in detecting prostate cancer, and more accurate in differentiating between localized and extracapsular disease. There are two important differences between the two papers. In the second paper, the authors claim that by using a different antibody epitope on the same molecule, the discrimination between organ-confined and non-organ–confined prostate cancer, which was a major finding in the first paper, is now nonexistent. Also, despite measuring the same protein (but targeting two different epitopes), the claimed optimal cutpoint in the first paper was 30 ng/mL (μg/L), while in the second the cutpoint was 0.5 ng/mL, nearly 2 orders of magnitude lower. Nevertheless, the authors concluded that the new data confirmed their.

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Pathology of RAD51

This protein is also found to interact with PALB2  and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis.
The Rad51 gene is located on chromosome 15 and several alterations of the gene have been associated with an increased risk of developing breast cancer. The breast cancer susceptibility protein BRCA2 and PALB2 controls the function of Rad51 in the pathway for DNA repair by homologous recombination. Increased RAD51 expression levels have been identified in metastatic canine mammary carcinoma, indicating that genomic instability plays an important role in the carcinogenesis of this tumor type.
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Parathyroid hormone-related protein, bone metastases and hypercalcaemia of malignancy

Breast cancer patients frequently develop bone metastases. A newly discovered peptide, Parathyroid Hormone Related Protein (PTHrP), causes humoral hypercalcaemia of malignancy. We have studied whether production of this protein by breast cancers leads to the development of bone metastases or hypercalcaemia. PTHrP was produced by nearly 60% of early breast cancers and its production by the tumours was associated with malignant mammographic microcalcification, and the development of both bone metastases and hypercalcaemia. The hypercalcaemia associated with bone metastases has been shown to have a significant humoral component and measurement of plasma PTHrP in patients with hypercalcaemia is diagnostically useful. Potential mechanisms of preventing bone metastasis are discussed.

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Solute carrier family's Profile

The solute carrier (SLC) group of membrane transport proteins include over 300 members organized into 52 families.  Most members of the SLC group are located in the cell membrane. The SLC gene nomenclature system was originally proposed by the HUGO Gene Nomenclature Committee (HGNC) and is the basis for the official HGNC names of the genes that encode these transporters. A more general transmembrane transporter classification can be found in TCDB database.
Solutes that are transported by the various SLC group members are extraordinarily diverse and include both charged and uncharged organic molecules as well as inorganic ions and the gas ammonia.
As is typical of integral membrane proteins, SLCs contain a number of hydrophobic transmembrane alpha helices connected to each other by hydrophilic intra- and extra-cellular loops. Depending on the SLC, these transporters are functional as either monomers or obligate homo- or hetero- oligomers.
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Introduction of sex hormones

Have a common biosynthetic pathway hormones: cholesterol precursor, by reducing the side chain to produce the first 21 carbon pregnenolone or progesterone, then the side chain to 19 carbon Evolution androgen, and then through the A-ring 18 generated by the carbon aromatized estrogen. Metabolic inactivation of sex hormones are basically the same way, that the formation of glucuronic acid ester or sulfate conjugates, such as water-soluble strong in the liver, kidney and other metabolic organ, and then with the urine, or with the bile into the intestines from the feces .
Sex hormones in the mode of action at the molecular level, as with the other steroid hormones, in combination with a specific receptor protein into the cell, the formation of the hormone - receptor complex then binds to the nucleus, acts on the chromatin DNA affects the transcription activity of Consequently, new or increased existing protein biosynthesis, and thus the regulation of cell metabolism, growth or differentiation. Hormones for small molecules, with a fat-soluble, mainly by free diffusion (passive transport) into the cell, combined with cytoplasmic receptors, forming a hormone - cytoplasmic receptor complexes, conformational changes and heat shock protein from the solution obtained by entering ability of the nucleus, transfer into the cytoplasm by the nucleus, nuclear hormone receptor binding with the formation of the hormone - receptor complex nucleus to stimulate transcription of the DNA to produce a specific mRNA, and then into the cytoplasm, the ribosome formation of protein translation play biological effects.

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Red ginseng extract - efficacy

1. To hyperglycemia caused by adrenaline animals has the effect of lowering blood sugar; Besides can consciously improve symptoms in patients with diabetes and mild fall blood sugar, and synergy with insulin.
2. Can promote animal sex gland function, mice eat small amounts of red ginseng, can produce the phenomenon for the tail.
(3) in the appropriate dose of rabbit can increase the weight, the ratio of plasma albumin and globulin increased.
4. Stimulate hematopoietic organs, improve the effect of anemia.
5. Long-term use of small, can make the reticuloendothelial system namely can hyperthyroidism; Dosage is too large, the opposite effect.

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Introduction of Acai Berry Extract

The Acai Berry is a good, natural way to aid in weight loss. Combined with proper diet and exercise, the Acai Berry will help you lose weight while also giving you additional health benefits, such as those heralded on shows like Oprah. Weight loss is just one reason this berry is being called "the number one super food." After taking Acai Berry supplements, many users also report the general feeling of well-being as the poisons, toxins and impurities are flushed from their systems, along with excess pounds. As you cleanse and detoxify, accumulated waste is removed from your colon, resulting in a weight loss of 4-12 pounds or more, often in as little as 14 days.
Acai Berry Extract Functions:
Reducing blood sugar and cholesterol and having the great effect to prevent hypertension;
Improving blood circulation and detoxification, enhancing immunity;
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Avena sativa - medical value

Avena sativa lower blood pressure, lower cholesterol, prevention and treatment of colorectal cancer, medicinal value and health care function, prevention and control of heart disease has been recognized by the medical profession ancient and modern, Chinese and foreign.
From July to October in 2011, lasted 121 days, the Beijing university school of medicine experts in baotou, Inner Mongolia region launched a germ naked Avena sativa m Ⅱ nursing intervention with type 1 diabetes in the scientific research activities, from 15 provinces and cities of the country's 404 people with diabetes, 96.5% of sugar friends pre-dinner postprandial blood sugar, glycosylated hemoglobin, fatty liver and pancreatic islet cells to repair the body all the indexes such as improved. All over the world for the first time with a crop to intervention in diabetes, and achieved fruitful results.
Due to liver, nephropathy, diabetes, fatty liver, caused by secondary hyperlipidemia has also obvious curative effect. Long-term consumption of Avena sativa meters, be helpful for control of diabetes and obesity.
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Astragalus Membranaceus Extract - efficacy

Astragalus Membranaceus is tonifying qi, such as boring talking, walking boring, complexion is white and so on all is the performance of the spleen and lung qi deficiency. Astragalus Membranaceus can fill a qi, qi deficiency such as upper body can use Astragalus Membranaceus, lower body deficiency can also use Astragalus Membranaceus.
Astragalus Membranaceus can reduce blood viscosity, reduce thrombosis, lower blood pressure and protect the heart, two-way regulating blood sugar, free radical damage resistance, aging resistance, resistance to hypoxia, anti-tumor, enhance immunity function, can be used to treat heart disease, high blood pressure, diabetes, etc. Astragalus Membranaceus can dilate blood vessels, improve skin blood circulation and nutrition, so effective for chronic ulcer for a long time does not heal. It also can eliminate proteinuria nephritis patients, protecting liver, prevent liver glycogen reduced.
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Jujube fruit extract - an overview

Jujube fruit fruit variety in north China is a high quality fresh food varieties. Jujube fruit belong to the rat lee branch, Jujube. Is a variety of stingless jujube fresh food varieties. Origin in China's shanxi yuncheng temple township, is now a large number of gardens located in shanxi, hebei, shandong, shanxi, xinjiang, and other places.
Its thin skin thicker, tender, juicy and chew without slag, concentrated sweet acid, taste good, the most appropriate table, vitamin content is 70 times that of apple, and pear 100 times, is of rich nutrition, is known as "live vitamin pills". Its core is small, with benevolence. Jujube fruit also contain more vitamin A, vitamin E, potassium, sodium, iron, copper and other trace elements, keep clear of the capillaries, the function of the blood vessels to prevent brittleness increases, have curative effect to hypertension, atherosclerosis disease, have anti-cancer effects.


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Pomegranate Peel extract - pharmacology

Disease-resistant original microbial effect: in vitro experiments showed that Pomegranate Peel on escherichia coli, shigella in song dynasty, proteus, salmonella typhi, paratyphoid coli, pseudomonas aeruginosa, vibrio cholerae of 7 kinds of gram-negative enteric pathogenic bacteria have inhibition. In vitro, Pomegranate Peel decoction of four kinds of dysentery bacillus have antibacterial effect, but the degree of differences, with the strongest effect on shigella 1:32 (0), the molisch, freund's next dysentery bacillus (8 0), and poor dysentery bacillus role within the song (1:20). Tablets antibacterial effect below test tube method. The antibacterial mechanism of action and its associated contains more tannic acid amount.
2. The insect repellent effect: fresh Pomegranate Peel and Pomegranate Peel decoction has contained a large amount of tannic acid, can make alkaloid of refractory, and cannot absorb compounds, which can fully function of intestinal parasites, make its muscles in the contracting state, therefore has the insect repellent effect. But the Pomegranate Peel toxicity is bigger, has now been better drug instead.
3. The other is according to the report, the female guinea pigs or rats served Pomegranate Peel powder can reduce after pregnancy.

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The function of spinach

1, im guide then, prevention and treatment of hemorrhoids: spinach contains a lot of plant crude fiber, can promote the intestinal peristalsis, defecation, and can promote the pancreas, to help digestion. For conditions such as hemorrhoids, constipation, anal fissure, chronic pancreatitis has a therapeutic effect; 2, promote the growth and development, enhance the ability of resistance: spinach contains carotene, in A converted into vitamin A, can maintain normal vision and the epithelial cells of health, increase the ability of prevention of infectious diseases, promote children's growth and development; 3, guarantee nutrition, better health: spinach is rich in carotene, vitamin C, calcium, phosphorus and a certain amount of iron, vitamin E and other beneficial ingredients, can supply the body a variety of nutrients; The iron, the adjuvant treatment of iron deficiency anemia have better;



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Learn more about Prunus Persica flower information

Prunus Persica flower, namely peach blooming flower, belongs to the rosaceae plants. Nearly spherical lobes elliptic-lanceolate, drupe, there are two main types of points GuoTao and peach flowers. Prunus Persica flower native to central China, north, is now widely cultivated in temperate countries and regions of the world, its propagation is given priority to with grafting. Prunus Persica flower can be made into Prunus Persica flower pill, Prunus Persica flower tea food. It has a high ornamental value, is the commonly used material of literary creation. In addition, Prunus Persica flower elements in dredge meridian, moist skin medicinal value. It says, and on behalf of the meaning is: a prisoner of love. In march every year, around in Prunus Persica flower as the media, held Prunus Persica flower festival event. Prunus Persica flower is a traditional Chinese garden flowers and trees, the tree a beautiful state, branches pond, flower well-developed, colour is gorgeous, as one of the important view of flower of spring.


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An introduction to the rhodiola rosea

For the perennial herb rhodiola rosea, 10 -- 20 cm tall. Roots thick, conical, fleshy, brown yellow, the neck, with most of the fibrous root, rhizome short, thick, cylindrical, most imbricate arrangement of scaly leaf. Alpine pollution-free zone growth in 1800-2500 meters above sea level, the growth conditions, thus has strong vitality and special adaptability. For medicinal, can fill gas clearing lung, educational yangxin, is blindly extensive role of traditional Chinese medicine. Also has a lot of cosmetic effect, can make skin care products, are edible. Alpine pollution-free growth in 1800-2500 meters above sea level of rare and precious wild plants hillside forests or slope, the elevations are mostly distributed in the northern hemisphere. Due to its growing conditions, such as oxygen, low temperature drying, high winds, ultraviolet light, large temperature difference between day and night, thus has strong vitality and special adaptability.

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Eating spinach guidelines

Appropriate crowd
In the general population are edible.
1. Soft and smooth after cooked spinach easy digest, especially suitable for the old, young, sick, weak consumption. Computer worker, the person that loves the should also often eat spinach.
Type 2 diabetes (especially Ⅱ) often eat spinach is beneficial to stable blood sugar.
3. Spinach is suitable for high blood pressure, at the same time in patients with constipation, anemia, scurvy, rough skin and allergies.
4. Not suitable for nephritis patients, patients with kidney stones. Spinach oxalic acid content is higher, eat shoulds not be too much at a time.
5. The other is unfavorable feed more loose stools pixu (spleen deficient).

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The function of theanine

Theanine since found, had been widely research as the main quality components of tea. In recent years, theanine has some special physiological function being discovered, and become the tea functional components synthesis and extraction, the application of another big heat, studies have shown that theanine has a number of valuable medicinal health function: (1) the blood pressure-lowering effect (2) to enhance the curative effect of antitumor drugs (3) relaxation effect such as nervousness, anxiety, (4) the protective effect of nerve cells (5) to promote brain function function (6) improve PMS (7) effect reducing weight (8) the anti-fatigue function (9), enhance immunity, defense against the virus.




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What is a black currant

Black currant, small shrubs, plant height, 50-150 cm, like light, cold resistance, barren resistance, developed root system. In the second year of engraftment see fruit, in the fifth year into the provinces.
The ripe fruit is small black berries, rich in vitamin C, anthocyanins, edible. Can also be processed into juice, jam, canned, beverage and other food. Black currant contains very rich in vitamin C, phosphorus, magnesium, potassium, calcium, anthocyanins and phenolic substances. At present already know that black currant health benefits including the prevention of gout, anemia, edema, arthritis, rheumatism, mouth and throat, cough, cardiovascular and cerebrovascular disease, high blood pressure, high cholesterol has very good effect.


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A brief introduction of Crambe oil

Crambe oil is an inedible seed oil, extracted from the seeds of the Crambe abyssinica, a multibranched annual plant that is native to the Mediterranean. The oil has been shown to consist of 55-60% erucic acid. The Australian Farm Diversification Information Service writes:Intermediate product derived from high erucic acid oil include: triglycerides; erucamides; amines, behenic acid; erucyl alcohol; behenyl alcohol; wax esters; fatty acids; brassylic acid and pelargonic acid. These products are used to manufacture a multitude of industrial consumer items such as lubricants; heat transfer fluids; surfactants and coatings; cosmetics; polyesters; plastics and nylons.Erucic acid is traditionally derived from older varieties of rapeseed. Crambe oil is considered to be a possible
replacement for rapeseed oil in this capacity. The market for crambe oil is particularly developed in the USA.


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A brief introduction of Glycyrrhizin

Glycyrrhizin for crystallization. Soluble in hot water; Ethanol, insoluble in ether actually, taste very sweet. Glycyrrhizin is an effective ingredient of liquorice sweetness, is a very promising natural sweetener, it has high sweetness (about 80-300 times of sucrose sweetness), low-calorie, safe non-toxic and strong health care efficacy, is high blood pressure, obesity, diabetes, heart disease patients with the most ideal sweetener, it can make up for sucrose sweeteners such as induced the disadvantages of the above diseases. Glycyrrhizin can promote the metabolism of bile pigment, lowering transaminase, at the same time have anti-inflammatory, anti-allergic and protective film structure, and so on.




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The application of honeysuckle

Honeysuckle slices can be roughly divided into crude drugs, medicine, c three kinds of medicine. It tastes and effect of three kinds of products are difference, also have good in application. Student is to put some samples honeysuckle after dry in the sun, shade or baking method for dried, also refers to some samples of flos lonicerae. Raw ingredients GanWei bitter, cold, good clear solution on coke and muscle table the poison of evil. Can be used in the initial stage of warm disease often associated with st John's wort, mint, SSP, herba schizonepetae, to strengthen the force of evacuation heat. Mainly used for the beginning of warm disease fever, the evil wind chill, micro thirsty, on behalf of the party, such as "fructus forsythiae powder". Can also be used for ulcer furunculosis, honeysuckle has since ancient times "the effective medicine of sores families," said. With dandelion, herba violae, wild chrysanthemum flower, such as share, can enhance the detoxification swelling effect. For ulcer furuncle poison, swelling pain, whether or not KuiNong KuiNong, using honeysuckle (the appropriate dosage of heavy) can play a good effect. On behalf of the party has a "five disinfection drink" and so on.



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Bromelain to cardiovascular disease prevention and control

Bromelain as proteolytic enzymes can be beneficial to the cardiovascular disease prevention.Bromelain in reducing the excessive buildup of platelets and reduce blood clots in the blood is also have the effect of above,Especially in the arterial blood. It can inhibit platelet aggregation in cause of heart attacks and strokes, alleviate symptoms of angina pectoris, moderate artery contraction,Acceleration of fibrinogen decomposition. Bromelain in vitro reduce human platelet aggregation, platelet in cattleAdsorption of endothelial cells and the formation of thrombus in mice.
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Acridine Raw Material

2 - propanol leakage treatment

Evacuation leakage pollution area personnel to safe areas, no irrelevant personnel enter the contaminated area, cut off the fire. Recommended emergency personnel to wear self-contained breathing apparatus, general fire wear protective clothing. Plugging in ensuring safety situation. Spray mist can reduce evaporation, but not reduce the leakage in the limited space of flammability. Mixed with sand or other incombustible adsorbent to absorb and use no spark tools collection to disposal of waste places. Can also use a lot of water to rinse, diluting the wash water into wastewater system. Such as a large number of leakage, use of cofferdam asylum, and then collect, transfer, recycling and harmless treatment after the waste.
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3-chloro-1-phenyl-1-propanol prices
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The use of methylamine

1 pesticide is mainly used for the production of dimethoate, monocrotophos, carbaryl, mixed off Granville, leafhoppers scattered metolcarb etc;
2 in the pharmaceutical industry for the synthesis of narcotics, stimulants, painkillers, antibiotics and other drugs.
3 Defense chemical industry, one, two methylamine can be used to produce high-quality liquid high-energy rocket fuel.
4 can also be used in the production of surfactants, water gel explosives, feed additives, developer, and other products.

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(1H-pyrazol-3-yl)methanamine prices
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Method for producing 4'-bromomethyl-2-cyanobiphenyl

Fifty grams (0.2591 mol) of 4'-methyl-2-cyanobiphenyl, 500 g of ethylene dichloride, and 4.0 g (0.0130 mol) of  2,2'-azobis(4-methoxy-2,4-dimethylvaleronitrile) were placed in a reaction vessel, and the internal temperature was controlled to 40°±2° C. Thereafter, 41.4 g (0.2591 mol) of Br 2 was added dropwise at the same temperature over a period of 2 hours, and then the reaction mixture was kept at that temperature for one hour.   At this point of reaction, samples were taken out from the reaction mixture, and they were subjected to LC analysis. As a result, it was found that the mixture contained 2.5% of the starting material, 92.0% of the monobromo-product, and 5.0% of the dibromo-product. Accordingly, the selectivity of the monobromo-product over the dibromo-product was 94.8%.  Thereafter, the reaction mixture was washed with 250 g of water, and then the mixture was separated to two layers. The organic layer was condensed by removing the solvent. The obtained solid was recrystallized from ethylene dichloride (150 ml)-n-heptane (600 ml), to give 63.1 g of 4'-bromomethyl-2-cyanobiphenyl with an LC purity of 99.0%. The yield was 89.4%, based on the starting material.

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Cadmium ingot Get La test Price and buy Metal powder

Cadmium ingot Get La test Price and buy Metal powder?Let's see together

Product Name:Cadmium ingot

Character:Silver grey, rectangular strip.

Package:Package:Plastic film, the net weight Of each spindle is 5-8 kg.

Application:Widely used in chemical industry, alloy, electroplating, battery and other industries.

Cadmium ingot Get La test Price and buy Metal powder?To learn more,visit http://www.metal-dust.com/products/Cadmium-ingot/

Superfine zinc powder for sale and how to buy Metal dust

Superfine zinc powder for sale and how to buy Metal dust?Let's see together

Product Name:Superfine zinc powder

Character:Gray powder.

Package:Metal pail packing,lined with plastic bags,pocket with rope lashes, barrelhead strong and seal,each net weight is divided into 25 kg,50 kg,etc.

Application:Widely used in large iron and steel member, shipping, aviation, container, metallurgy, chemical industry, agriculture and forestry, medicine, dyestuff, batteries, etc

Product category:Leading product

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Information about Iron oxide nanoparticles and How to buy Metal dust?

Information about Iron oxide nanoparticles and How to buy Metal dust?Let's see together

Product Name: Iron oxide nanoparticles

Product Description:  Iron oxide nanoparticles are iron oxide particles with diameters between about 1 and 100 nanometers. The two main forms are magnetite (Fe3O4) and its oxidized form maghemite (γ-Fe2O3). They have attracted extensive interest due to their superparamagnetic properties and their potential applications in many fields (although Cu, Co and Ni are also highly magnetic materials, they are toxic and easily oxidized).

Application: Terabit magnetic storage devices, catalysis, sensors, and high-sensitivity biomolecular magnetic resonance imaging (MRI) for medical diagnosis and therapeutics. These applications require coating of the nanoparticles by agents such as long-chain fatty acids, alkyl-substituted amines and diols.

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A brief introduction 15321-51-4 Nonacarbonyldiiron Price and availability

A brief introduction 15321-51-4 Nonacarbonyldiiron Price and availability.Powder metallurgy is the process of blending fine powdered materials, pressing them into a desired shape or form (compacting), and then heating the compressed material in a controlled atmosphere to bond the material (sintering)

A brief introduction 15321-51-4 Nonacarbonyldiiron Price and availability

Product Name:  Nonacarbonyldiiron

Molecular formula : Fe₂(CO)₉    

CAS number: 15321-51-4

Product Description: Golden flake crystals. 100 ℃ decomposition. And it is different from general metal carbonyl compounds . This product's vapor pressure is very low, insoluble in organic solvent, also has no the reaction with it, and used in organic synthesis, essence, perfume industry. For example, respectively has reaction with the sulfur, organic sulphur and phenyl phosphonic, can  generate iron sulfur compounds atom clusters including inorganic sulfur, sulfur hydrocarbon(RS), including the phenyl phosphonic(phPH2)  mixed ligands more coordination compounds, carbonyl iron the product all has certain reaction and lively, have value of the study on the reaction mechanism.

A brief introduction 15321-51-4 Nonacarbonyldiiron Price and availability.To learn more, visit http://www.metal-dust.com/products/Nonacarbonyldiiron/

how much does Graphite plating iron and nickel cost?

how much does Graphite plating iron and nickel cost?These highly specialized membranes are successfully replacing centrifugation, extraction, and rotary vacuum filters. We invite you to take advantage of our deep experience in this arena.

how much does Graphite plating iron and nickel cost?

Product Name: Graphite plating iron and nickel
Product Description: Graphite is proved to be the most thin, the hardest substance in the world. Based on its chemical structure, graphite has many unique chemical and physical properties, such as high surface area, high conductivity, high mechanical strength, easy to modify and large scale production, etc.

how much does Graphite plating iron and nickel cost?To learn more, visit http://www.metal-dust.com/products/Graphite-plating-iron-and-nickel--/

Metal ceramic MIM coated with iron nickel ceramic powder for sale for sale

Metal ceramic MIM coated with iron nickel ceramic powder for sale.

Metal ceramic MIM coated with iron nickel ceramic powder for sale

Product Name:  Metal ceramic MIM coated with an iron nickel ceramic powder
Product Description: Iron nickel coating graphite conductive filler is made from the heated graphite decompositing Fe(CO)5 and Ni(CO)4 . A high rate of coating, coating is adjustable , high conductivity, overcome the same products in abroad  up to 70% the amount of coating and the coating rate is still low, and the price is far lower than the same products abroad.

Metal ceramic MIM coated with iron nickel ceramic powder for sale.To learn more, visit http://www.metal-dust.com/products/Metal-ceramic-MIM-coated-with-iron-nickel-ceramic-powder/

What's a Pt nanopowder Description CAS No.:7440-06-4

What's a Pt nanopowder Description CAS No.:7440-06-4,A nanopowder is an extremely fine powder produced on the nano scale for applications in industry and research. 

What's a Pt nanopowder Description CAS No.:7440-06-4

Product name :  Pt nanopowder

Chemical Name :Platinum Nanoparticles(Pt)

CAS No. : 7440-06-4

Specification :

Purity	99.9% (metal basis); 99.99%
APS	10nm
Color	Black
SSA	40-60 m2/g

What's a Pt nanopowder Description CAS No.:7440-06-4.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

To learn more, visit http://www.nano-powders.net/Metal-nanopowder/Pt-nanopowder/

A brief introduction Nickel-copper alloy nanopowder explain

A brief introduction Nickel-copper alloy nanopowder explain,

Product name：Nickel-copper alloy nanopowder
Chemical formula：Ni-Cu   
Grainsize：50nm 
Purity：99.90% 
Specific surface area：12.3m2/g
Density：0.15g/cm3

A brief introduction Nickel-copper alloy nanopowder explain.For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

To learn more, visit http://www.nano-powders.net/Alloy-nanopowder/Nickel-copper-alloy-nanopowder/