CD166 's Introduction

Activated leukocyte cell adhesion molecule (ALCAM; CD166) is a 105 kD cell-surface adherence atom acceptance to the Ig superfamily of receptors. ALCAM is a blazon I transmembrane glycoprotein, possessing 5 extracellular Ig domains, a transmembrane domain, and a abbreviate cytoplasmic tail. ALCAM is complex in homotypic adhesion, as able-bodied as heterotypic adherence with its accustomed ligand, CD6. A acrid isoform of ALCAM has been apparent to arrest homophilic adhering interactions. ALCAM is bidding on a array of corpuscle types, including activated T and B cells, monocyte-derived blooming cells, and thymic epithelial cells. ALCAM announcement has aswell been acclimated as a brand for the abreast of pluripotent axis cells.