Product name:NF kappa B p65 phospho-Ser536 RELA Polyclonal Antibody
Specification:100 µg
Applications:ELISA, IHC-P, WB-Ce
Immunogen:Rabbit polyclonal antibiotic aloft adjoin constructed phosphopeptides of RELA.
Description:NFKB1 (MIM 164011) or NFKB2 (MIM 164012) is apprenticed to REL (MIM 164910), RELA, or RELB (MIM 604758) to anatomy the NFKB complex. The p50 (NFKB1)/p65 (RELA) heterodimer is the a lot of abounding anatomy of NFKB. The NFKB circuitous is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 or NFKBIB, MIM 604495), which inactivate NFKB by accoutrement it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664, or IKBKB, MIM 603258) marks them for abolition via the ubiquitination pathway, thereby acceptance activation of the NFKB complex. Activated NFKB circuitous translocates into the basis and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).
Read More:Buy NF kappa B p65 phospho-Ser536 RELA Polyclonal Antibody
From: Phosphorylates
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