The role of tumor protein p53 phosphorylation Tyr18 TP53 polyclonal antibodies

Tumor protein p53, nucleoprotein, the adjustment of the corpuscle aeon plays a basic role, abnormally in the alteration from G0, G1. It is begin in actual low levels, in accustomed cells, but in a array of adapted corpuscle lines, it is bidding in top volume, and believed to accord to the transformation and malignancy. The p53 gene is a DNA-binding protein, absolute the DNA bounden oligomerization and transcriptional activation domain. It is affected that the p53-binding sites on the tetramer bounden and activation of after gene announcement in inhibiting the advance and / or invasion, and functions as a bump suppressor. Fail to bind the p53 mutants, generally occurs in a amount of altered animal blight accord DNA bounden sites, and accordingly advance to bump abolishment action loss. The TP53 gene change occurs not alone in animal cancerous actual mutation, but the Li-Fraumeni affection mutations in assertive cancer-prone families.
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