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Anti-FBN1 (fibrillin 1) basic information

Product name: Anti-FBN1 (fibrillin 1)
Description: Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene.
This gene encodes a member of the fibrillin family. The encoded protein is a large, extracellular matrix glycoprotein that serve as a structural component of 10-12 nm calcium-binding microfibrils. These microfibrils provide force bearing structural support in elastic and nonelastic connective tissue throughout the body. Mutations in this gene are associated with Marfan syndrome, isolated ectopia lentis, autosomal dominant Weill-Marchesani syndrome, MASS syndrome, and Shprintzen-Goldberg craniosynostosis syndrome.


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Anti-HEV in some applications

Anti-HEV IgM and IgG can be divided into two kinds of antibodies, Anti-HEV IgM and recent infection, infection in the early liver E (around the beginning of the acute phase) appears to last about five months and then disappears. Anti-HEV IgG appeared later than IgM, may be present in the body at least 5 years of infection indicators for ever. But many studies have shown, E liver antibody (either IgM or IgG) is not a good indicator of infection, since confirmed by PCR in patients with acute liver E, often undetectable Anti-HEV IgM or IgG, expressed antibody sensitivity is poor. Therefore, only the reference antibody measurement results can not be used as a basis for diagnosis.
E liver virus and hepatitis A infection pathway similar to fecal-oral infection based. E liver infection mostly sporadic cases of outbreak (outbreaks) occur rarely. Study found that regional epidemic E liver and contaminated water mostly related to improvement in water control, the new cases disappear. E liver incubation period of about 2 to 10 weeks, the majority of patients with flu-like symptoms appear, a few evolve into acute hepatitis, but it will not develop into chronic hepatitis or cirrhosis.
E and A liver infection liver age is slightly different, A liver infection in childhood when, and E in the liver and more infected between the ages of 15-40. Hepatitis E cases, cases of acute deterioration of liver more than A, especially pregnant women infected with hepatitis E, its mortality rate can be as high as 20%.


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Anti-HCV-Core of some description

HCV gene structure:
HCV is a positive spherical enveloped single-stranded RNA viruses. HCV genome is a single strand RNA, total length of about 9500 bases. Genome sides were 5 'and 3' non-coding region, in the middle of an open reading frame (ORF), divided into structural and non-structural region area (Figure 1). Structural protein region including the core region (C) and two envelope protein region (E1, E2), respectively, encoding core protein and envelope proteins. Non-structural protein region including NS2, NS3, NS4 and NS5 region encoding functional proteins, such as proteases (NS2, NS3 and NS4A area), helicase (NS3) and RNA-dependent RNA polymerase (NS5B region). Although the non-structural protein is not part of the virus particle, but in viral replication plays a very important role. Now commonly used genetically engineered to express the structural and non-structural proteins as coating antigen to create anti-HCV ELISA detection method. HCV genome has significant heterogeneity, different sections of the same degree of variation in the genome there are significant differences. 5 'non-coding region most conservative, so PCR detection of HCV, RNA primer design more choice in the region.

Anti-HCV (Anti-HCV-Core) is the hepatitis C virus antibodies.
It is currently the most widely used for epidemiological investigation, clinical hepatitis C screening and diagnostic test items. So far the method detection of anti-HCV continuous improvement. With the improved method, the sensitivity and specificity of a gradual increase.
Referred to as the hepatitis C virus HCV, the classification of the virus are positive-strand RNA viruses, is considered to be caused by the early non-A, non-B hepatitis virus (non-A, non-B viral hepatitis) one of the major virulence factors. Was discovered in 1978, in 1989 obtained by gene technology was first genome sequence. It is a large 45 nm, with a housing, the single-stranded RNA virus, which belongs to the Flaviviridae virus is hepatitis. According to the 1994 establishment of the new classification system, HCV can be divided into six different genotypes (Genotype) and 30 subtypes (subtype). Mainly in Europe and Japan, mainly type 1, and the second type in Japan, China, mostly in the third type in Thailand, Singapore, India, and most of the more common in Egypt, the Middle East and central Africa, mainly type 4, The Type 5 and Type 6 is more common in South Africa and Southeast Asia. Hepatitis C only infect humans. As the name implies, namely anti-HCV hepatitis C virus antibodies.

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Anti-HO-2 (Heme oxygenase 2) information about the

Heme oxygenase (Anti-HO-2 (Heme oxygenase 2)) is in the process of heme catabolism rate-limiting enzyme in the human body of CO is dominated by heme oxygenase (HO) metabolites produced. HO There are three types: oxidative stress inducible (HO-1), constitutive (HO-2) and remained clear HO-3. Studies show that, HO-1 in the body not only play a role in the physiological state, but mainly in the body, or other non-normal stress play a role. HO-2 is mainly distributed in the central nervous system and testicular, HO-2 CO produced in the nerve plays an important role in signal transduction, and CO neurotransmitters play closely related. Many scholars on ways to produce CO and HO carried out a detailed study that through this - pathways of CO speed and quantity of 0.4ml / h (16.4/μmol/h). It is known HO distributed in almost all the organs and tissues, and involves the growth process, which prompts the production of CO can be very wide area. Currently a large number of studies have confirmed CO is important in vivo cell messenger, heart, brain and vascular system plays an important biological effect, involved in the regulation of many physiological and pathological processes in vivo. Meanwhile, CO as a novel neurotransmitter is also cause for concern, and its role in the nervous system and its clinical significance in research, neuroscience has become a new hotspot.

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mGluR5 (Anti-GRM5 (Glutamate Receptor Metabotropic 5)) gene structure

First reported in 1985 Glu Sladeczek activation of G protein-coupled receptors. 1991 Houamed etc. from rat cerebellum cDNA library cloned out of the mGluR1. 1992 年 researchers mGluR1 probe made ​​from mouse brain cDNA library isolated mGluR5 (Anti-GRM5 (Glutamate Receptor Metabotropic 5)）. mGluR5 length of the cDNA is 3 918bp, encoding a 171 amino acid residues, a molecular weight of 128 289. mGluR5 consists of three parts: The first part is the function of the extracellular region, including the 560 amino acid residues, which has the potential glycosylation of tion sites, a signal peptide of the N-terminal; second portion by a hydrophobic region 7 formed in the cell membrane seven transmembrane region, this area has 261 amino acid residues; third part is the function of the cell area, the 350 amino acid residues, the C-terminal phosphorylation sites are many and threonine, serine residue, suggests that this region may be adjusted several kinase receptor target [3] in the human and rat mGluR5 7th a transmembrane region of the cytoplasm and after the insertion end 50, respectively, and 32 amino acid residues, does not cause GluR5 pharmacological properties of the changes, which will initially be cloned mGluR5 named mGluR5a, the named after insertion mG1uR5 mGluR5b, in the adult rat brain mG1uR5b mRNA expression than mGluR5a.

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