The role of the 5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium

Antacids and antiulcer drugs: 5 - (Difluoromethoxy) - 2 - (((3, 4 - dimethoxy - 2 - pyridinyl) methyl) sulfinyl) 1 h - benzimidazole sodium is also called pan tora azole sodium, Northumberland, Pan Meilu, Locke, pan is a kind of peptic ulcer and acid resistance, spasmolysis medicine, clinical correlation is mainly used in the acid treatment, such as the duodenal ulcer, gastric ulcer, reflux esophagitis, acute gastric mucosa lesion compound ulcer and other acute upper gastrointestinal bleeding, zhuo - ai syndrome, acute pancreatitis and stress ulcer.

Pharmacological effects: this product through specific effect on gastric mucosal cell wall and lower wall cells of H +, K + atpase activity, thus inhibiting the secretion of stomach acid. Compared with omeprazole, panxi tora azole sodium of cytochrome P450 enzyme inhibition is weak.

Panxi tora azole sodium and omeprazole, sola azole cells proton pump inhibitors are the lining of the stomach, is relatively stable in neutral and weak acid conditions, under the condition of strong acid activation, quickly the pH dependence of activation feature, make it to the effect of H +, K + atpase has better selectivity.

Pharmacokinetic: oral absorbed quickly and completely, after a single oral 40 mg after 2 ~ 3 hours to reach peak blood drug concentration, its oral preparations of absolute bioavailability of 77%, panxi tora azole sodium plasma protein union rate of 98%, mainly in the liver metabolism to methyl panxi tora azole sulfate. Half-life 1 hour or so, to methyl panxi tora half-life of sulfate 1 ~ 5 hours. 80% of the metabolites by the kidneys, and the rest by bile into the droppings.

Drug interactions: diazepam tora azole sodium small interactions with other drugs, compared with omeprazole, small effect on the cytochrome P450 system, does not affect the stability and the role of the time, and oral contraceptives, digoxin, warfarin, phenytoin sodium or theophylline has no obvious interaction.

Adverse reactions and precautions: adverse reactions to occasional dizziness, insomnia, drowsiness, nausea, diarrhea, constipation, skin rashes and muscle pain, large dose use can appear arrhythmia, amino transferase rise, changes in renal function, granulocytopenia. Liver and renal insufficiency and children with caution. Pregnancy and lactation women are prohibited.

Purpose: 1 antacids and antiulcer drug, for gastric and duodenal ulcer. 2 antacids and antiulcer drug for the treatment of gastric and duodenal ulcer disease

More about:5-(Difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) sulfinyl)-1H-benzimidazole sodium suppliers
From:Natural herbal extracts