Acitretin (trade name Soriatane or Neotigason) is a second-generation retinoid. It is taken orally, and is about acclimated for psoriasis.
It is a metabolite of etretinate, which was acclimated above-mentioned to the addition of acitretin. Etretinate was discontinued because it had a attenuated ameliorative basis as able-bodied as a continued abolishment half-life (t1/2=120 days), authoritative dosing difficult. In contrast, acitretin's half-life is about 2 days. However, because acitretin can be about-face metabolised into etretinate which has an acutely continued half-life, women accept to abstain acceptable abundant for at atomic 3 years afterwards alternate acitretin. Therefore, acitretin is about not recommended for women of changeable age with a accident of acceptable pregnant.
Acitretin is an articulate retinoid acclimated in the analysis of astringent aggressive psoriasis. Because of the abeyant for problems and astringent ancillary furnishings it is about acclimated in alone actual astringent cases of crawling that accept been above to added treatments. It binds to nuclear receptors that regulates gene transcription. They abet keratinocyte adverse and abate epidermal hyperplasia, arch to the slowing of corpuscle reproduction. Acitretin is readily captivated and broadly broadcast afterwards articulate administration. A ameliorative aftereffect occurs afterwards 2 to 4 weeks or longer.
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