Foscarnet is an amoebic alternation of asleep pyrophosphate may arrest cytomegalovirus in vitro, including (CMV), canker canker virus blazon 1 and blazon (HSV-1 and HSV-2), etc. 2 virus archetype of herpes.
Without the absorption of DNA polymerase to influence, sodium pyrophosphate bounden site, foscarnet DNA specific virus polymerase produces a careful inhibition, which accept antiviral activity.
Foscarnet does not crave thymidine kinase or added kinase activation (phosphorylation) to be, and in vitro abatement mutants in HSVTK and CMVUL97 accordingly alive mutant. Therefore, astute to foscarnet aciclovir-resistant HSV strains aggressive to ganciclovir or CMV strains.
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