Epsilon polylysine - can be used as food additives

Epsilon-polylysine (epsilon-PL) has been acclimated as a aliment accretion in Japan for abounding years. In this study, it inhibited animal and beefy pancreatic lipase action in substrate emulsions absolute acerbity salts and phosphatidylcholine, in the assimilation ambit of 10-1000 mg/L. At the aforementioned concentrations, it aswell destroyed the emulsifying activity, suggesting that lipase inhibitory action and chrism breakdown action were associated. Epsilon-PL inhibited beefy pancreatic lipase action and destroyed chrism breakdown action at 1000 mg/L in the substrate absolute acerbity salts and phosphatidylcholine alone. Epsilon-PL did not arrest lipase action or affect emulsifying action at 1000 mg/L in the substrates absolute arabic gum and polyvinyl alcohol. A allegory of lipase inhibitory action amid epsilon-PL and three types of alpha-PL with differing polymerization ante was performed. The lipase inhibitory action of epsilon-PL was not altered from that of alpha-PL (44 lysine residues). Epsilon-PL maintained its inhibitory action afterwards evolution with trypsin, alpha-chymotrypsin and pepsin, admitting alpha-PL did not. The aftereffect of epsilon-PL on postprandial hypertriacylglyceridemia was advised in rats. The claret triacylglycerol assimilation in rats intragastrically administered > or =15 mg/kg of both fat chrism and epsilon-PL was decidedly lower at 2 and 3 h afterwards administering than that in rats administered fat chrism abandoned (P < 0.05). These after-effects acerb advance that epsilon-PL is able to abolish comestible fat assimilation from the baby civil by inhibiting pancreatic lipase activity.
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