The Anti-CTBP1（C-terminal binding protein 1） Products

Anti-CTBP1（C-terminal bounden protein 1）Details

Antigen Specificity: Polyclonal antibiotic produced in rabbits immunized with a constructed peptide agnate to a arena of Human CTBP1. ELISA Titre: 1:62500 Note: Suggested starting concentrations are provided. Optimal dilutions should be bent by end-user. Differences in affected against credible atomic weight may be due to post-translational modifications or protein hydrophobicity. CTBP1 binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the artefact of a additional carefully accompanying gene. CTBP2. can dimerize. Both protei

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.

Summary: This protein is a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the artefact of a additional carefully accompanying gene, CTBP2, can dimerize. Both proteins can aswell collaborate with a polycomb accumulation protein circuitous which participates in adjustment of gene announcement during development. Alternative splicing of transcripts from this gene after-effects in assorted archetype variants. Spyer.M.. et al.. (2006) Cell Cycle 5 (5). 530-537.

anti-CtBP1 (C-terminal Bounden Protein-1), Clone: 3.

Transcriptional repression is analytical for abiogenetic adjustment of abounding cellular proteins, and involves either a archetype regulator that has an built-in repressor domain, or a archetype regulator that contains a bounden website in the authoritative area area a corepressor can bind. C-terminal bounden proteins (CtBP1 and CtBP2) are a chic of corepressors that collaborate with a subset of archetype factors through a PLDLSL arrangement motif. CtBP1 and CtBP2 are 80% homologous, and both are bidding at top levels in beginning tissues. However, CtBP1 is bidding college in developed tissues, and is added broadly bidding in beginning and developed tissues. Both CtBP1 and CtBP2 bind the dEF1 zinc finger-homeodomain archetype factor, and enhance transcriptional repression via alternation with the PLDLSL-sequence in dEF1. CtBP1 and CtBP2 bind added zinc feel archetype factors, including Kheper and BKLF. In addition, CtBP2 interacts with added archetype factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important corepressors for a array of transcriptional factors.

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